Method of speech enhancement using Neural Network-based combined signal starts with training neural network offline which includes: (i) exciting at least one accelerometer and at least one microphone using training accelerometer signal and training acoustic signal, respectively. The training accelerometer signal and the training acoustic signal are correlated during clean speech segments. Training neural network offline further includes(ii) selecting speech included in the training accelerometer signal and in the training acoustic signal, and (iii) spatially localizing the speech by setting a weight parameter in the neural network based on the selected speech included in the training accelerometer signal and in the training acoustic signal. The neural network that is trained offline is then used to generate a speech reference signal based on an accelerometer signal from the at least one accelerometer and an acoustic signal received from the at least one microphone. Other embodiments are described.