An interference suppression system comprises an antenna, a control module, a receiving and sending module, a radio frequency (RF) sending channel, a power amplifier (PA), a RF receiving channel, a first filter module, and a power detecting module. The control module adjusts the first filter module frequency band to achieve filter feedback to the PA input end. The interference suppression system applies multiple feedbacks to enhance suppression capability, and reduces interference from RF sending channel to RF receiving channel because of PCB signal leakage and mutual interference between this system and adjacent systems.