A framework for combining a weather risk analysis with appropriate operational rules includes a data initialization component, a rules processing component, and one or more weather risk analysis and assessment tools to evaluate a flight condition. The framework applies current, historical, predicted and forecasted weather data to the one or more operational rules governing a mission, a payload, a flight plan, a craft type, and a location of the mission for aircraft such as an unmanned aerial vehicle or remotely-piloted vehicle, and generates advisories based on the evaluation of flight conditions such as a mission compliance status, instructions for operation of unmanned aircraft, and management advisories. The flight condition advisories include either a “fly” advisory or a “no-fly” advisory, and the framework may also provide a mission prioritization and optimization system.