Invention Grant
- Patent Title: Highly diverse combinatorial antibody libraries
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Application No.: US14419881Application Date: 2013-09-02
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Publication No.: US10040870B2Publication Date: 2018-08-07
- Inventor: Johannes Joseph Wilhelmus De Haard , Christophe Frederic Jerome Blanchetot , Alex Klarenbeek , Ikbel Achour , Khalil El Mazouari , Jurgen Del Favero
- Applicant: argenx BVBA
- Applicant Address: BE Zwijnaarde
- Assignee: argenx BVBA
- Current Assignee: argenx BVBA
- Current Assignee Address: BE Zwijnaarde
- Agency: Lathrop Gage LLP
- Agent James H. Velema, Esq.
- International Application: PCT/EP2013/068110 WO 20130902
- International Announcement: WO2014/033304 WO 20140306
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/46
Abstract:
Disclosed is an immune library obtained from a Camelid species containing at antibody chains belonging to at least 7 human germline antibody chains. The presence of a large number of human germline antibody chain families in the library contributes to the usefulness of the library in producing antibodies to human target antigens. The antibodies produced from the library have low inherent immunogenicity.
Public/Granted literature
- US20150166680A1 HIGHLY DIVERSE COMBINATORIAL ANITBODY LIBRARIES Public/Granted day:2015-06-18
Information query
