Invention Grant
- Patent Title: 1,3,4-thiadiazole compounds and their use in treating cancer
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Application No.: US15362989Application Date: 2016-11-29
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Publication No.: US10040789B2Publication Date: 2018-08-07
- Inventor: David Robert Perkins , Maurice Raymond Verschoyle Finlay , Johannes Wilhelmus Maria Nissink , Piotr Antoni Raubo , Peter Duncan Smith , Andrew Bailey
- Applicant: AstraZeneca AB , Cancer Research Technology Limited
- Applicant Address: SE Sodertalje GB London
- Assignee: AstraZeneca AB,Cancer Research Technology Limited
- Current Assignee: AstraZeneca AB,Cancer Research Technology Limited
- Current Assignee Address: SE Sodertalje GB London
- Agent Daniel Kopp
- Main IPC: C07D417/14
- IPC: C07D417/14 ; A61K31/433 ; A61K31/501

Abstract:
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, is described. Q can be pyridazin-3-yl, 6-fluoropyridazin-3-yl; R1 can be H; R2 and R3 can each independently be C1-C6 alkyl, or R2 and R3 taken together are —(CH2)3—; or R1 and R2 taken together can be —(CH2)2— and R3 can be —CH3; R4 halo, —CH3, —OCH3, —OCHF2, —OCF3, or —CN; and n can be 0, 1, or 2. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.
Public/Granted literature
- US20170333429A1 1,3,4-Thiadiazole Compounds and Their Use in Treating Cancer Public/Granted day:2017-11-23
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