Process for preparing a polymorph of rivaroxaban
Abstract:
This invention describes a process for the preparation of rivaroxaban modification I comprising: (i) dissolving rivaroxaban in a mixture of a solvent (e.g. THF) and an antisolvent (e.g. water and/or toluene), wherein the antisolvent has a higher boiling point than the solvent; (ii) removing the solvent by distillation; and (iii) collecting the resultant rivaroxaban modification I.
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