Invention Grant
- Patent Title: Process for preparing a polymorph of rivaroxaban
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Application No.: US15520499Application Date: 2015-10-22
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Publication No.: US10040786B2Publication Date: 2018-08-07
- Inventor: Karol Sagol , Magdalena Kozien-Sajnog
- Applicant: Zaklady Farmaceutyczne Polpharma SA
- Applicant Address: PL
- Assignee: ZAKLADY FARMACEUTYCZNE POLPHAMRA SA
- Current Assignee: ZAKLADY FARMACEUTYCZNE POLPHAMRA SA
- Current Assignee Address: PL
- Agency: Wood, Phillips, Katz, Clark & Mortimer
- Priority: EP14460075 20141022
- International Application: PCT/EP2015/074538 WO 20151022
- International Announcement: WO2016/062828 WO 20160428
- Main IPC: C07D413/14
- IPC: C07D413/14 ; C07D265/32 ; C07D333/38 ; C07D413/12

Abstract:
This invention describes a process for the preparation of rivaroxaban modification I comprising: (i) dissolving rivaroxaban in a mixture of a solvent (e.g. THF) and an antisolvent (e.g. water and/or toluene), wherein the antisolvent has a higher boiling point than the solvent; (ii) removing the solvent by distillation; and (iii) collecting the resultant rivaroxaban modification I.
Public/Granted literature
- US20170313689A1 PROCESS FOR PREPARING A POLYMORPH OF RIVAROXABAN Public/Granted day:2017-11-02
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