Invention Grant
- Patent Title: Reversing intestinal inflammation by inhibiting retinoic acid metabolism
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Application No.: US15464010Application Date: 2017-03-20
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Publication No.: US10039751B2Publication Date: 2018-08-07
- Inventor: Hweixian Leong Penny , Edgar George Engleman , Nupur Bhattacharya
- Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Applicant Address: US CA Stanford
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Stanford
- Agency: Bozicevic, Field & Francis LLP
- Agent Kyle A. Gurley
- Main IPC: A61K31/428
- IPC: A61K31/428 ; A61K31/4184 ; A61K9/00
Abstract:
An agent that increases local concentration of retinoic acid (RA) in the intestine through modifying enzymatic pathways involved in RA metabolism is administered in a dose effective to inhibit or reverse production of inflammatory mediators by intestinal dendritic cells and thereby reduce intestinal inflammation and tumor growth associated with intestinal inflammation.
Public/Granted literature
- US20170189384A1 REVERSING INTESTINAL INFLAMMATION BY INHIBITING RETINOIC ACID METABOLISM Public/Granted day:2017-07-06
Information query
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