[Object] The present technique relates to an image pickup device, an image pickup method, and a program that enables pixels having 4 types of spectral sensitivities to be controlled while changing exposure times.[Solving Means] The present technique is applicable to an image pickup device including pixels having 4 types of spectral sensitivities, that include pixels having a panchromatic spectral sensitivity and are arranged on an image pickup surface, pixels that realize a first exposure and pixels that realize a second exposure different from the first exposure being arranged on the image pickup surface with respect to the 4 types of spectral sensitivities. Further, a first line in which first pixels having the panchromatic spectral sensitivity are arranged in a two-pixel cycle in a specific direction and a second line in which the first pixels are arranged while deviating by one pixel from the first line in the specific direction are arranged alternately in a direction orthogonal to the specific direction, and pixels having spectral sensitivities different from the spectral sensitivity of the first pixels are arranged in a 2- or 4-pixel cycle in the specific direction for each of the spectral sensitivities and 2-dimensionally constitute a cyclic arrangement of 4×4 pixels in which the first spectral sensitivity pixels are arranged in a checkerboard arrangement.