Invention Grant
- Patent Title: Substituted spirocyclic inhibitors of autotaxin
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Application No.: US15300762Application Date: 2015-04-03
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Publication No.: US10011601B2Publication Date: 2018-07-03
- Inventor: Lee Babiss , Matthew Clark , Anthony D. Keefe , Mark J. Mulvihill , Haihong Ni , Louis Renzetti , Frank Ruebsam , Ce Wang , Zhifeng Xie , Ying Zhang
- Applicant: X-Rx, Inc.
- Applicant Address: US MA Waltham
- Assignee: X-Rx, Inc.
- Current Assignee: X-Rx, Inc.
- Current Assignee Address: US MA Waltham
- Agency: Clark & Elbing LLP
- International Application: PCT/US2015/024338 WO 20150403
- International Announcement: WO2015/154023 WO 20151008
- Main IPC: C07D221/00
- IPC: C07D221/00 ; C07D233/00 ; A61K31/4545 ; A61K31/415 ; A61K31/445 ; A61K31/454 ; C07D471/10 ; A61K45/06 ; A61K31/435 ; A61K31/437 ; A61K31/444 ; A61K31/498 ; A61K31/517 ; A61K31/538 ; A61K31/69 ; C07D519/00 ; C07F5/02
Abstract:
The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
Public/Granted literature
- US20170166568A1 SUBSTITUTED SPIROCYCLIC INHIBITORS OF AUTOTAXIN Public/Granted day:2017-06-15
Information query
