- Patent Title: Precursor compound of radioactive halogen-labeled organic compound
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Application No.: US14872305Application Date: 2015-10-01
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Publication No.: US10010632B2Publication Date: 2018-07-03
- Inventor: Osamu Ito , Akio Hayashi , Fumie Kurosaki , Masahito Toyama , Toshiyuki Shinmura , Arinori Harano
- Applicant: NIHON MEDI-PHYSICS CO., LTD.
- Applicant Address: JP Tokyo
- Assignee: NIHON MEDI-PHYSICS CO., LTD.
- Current Assignee: NIHON MEDI-PHYSICS CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Fitch, Even, Tabin & Flannery LLP
- Priority: JP2005-343653 20051129
- Main IPC: A61M36/14
- IPC: A61M36/14 ; A61K51/04 ; C07B59/00 ; C07C309/65 ; C07C67/307

Abstract:
It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [18F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; R1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by —OR2; R2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R3 is a protective group.
Public/Granted literature
- US20160082135A1 PRECURSOR COMPOUND OF RADIOACTIVE HALOGEN-LABELED ORGANIC COMPOUND Public/Granted day:2016-03-24
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