The invention provides a system, a method and a device for data distributed encryption and decryption, an electronic device and a medium. The system comprises: a master node, used for receiving an encryption and decryption request of specified data sent by a requester, dividing the specified data into segmented data according to a set segmented length, determining a segmented secret key of each segmented data, and sending the segmented data, the segmented secret keys and the segmented numbers to at least two slave nodes, and the segmented secret keys corresponding to the segmented data are different; and at least two slave nodes, used for encrypting and decrypting the segmented data according to the segmented key, and sending the encrypted and decrypted segmented data and the segmented number to the master node. The main node is also used for assembling the encrypted and decrypted segmented data into encrypted and decrypted data according to the segment number and returning the encrypted and decrypted data to the requester. According to the invention, the master node uniformly receives the encryption and decryption request and distributes the segmented data to the slave node for encryption and decryption, and the keys of the segmented data are different, so that the risk of key leakage is reduced, and the security of the data is improved.