The invention relates to a VTiCuHfZr high-entropy alloy and a preparation method thereof. The component of the high-entropy alloy is VTiCuHfZr, and the molar ratio of V to Ti to Cu to Hf to Zr is 1:1:1:1:1. The preparation method comprises the following preparation processes: 1) ultrasonic treatment: performing material ultrasonic treatment for later use; 2) accurate weighing: accurately weighingmaterials at an equimolar ratio; 3) placing of the materials in crucibles: placing a titanium material and the weighed materials in the crucibles; 4) repeated washing: inflating argon and repeatedly and circularly washing a vacuum chamber after vacuumizing; and 5) alloy melting: melting the materials repeatedly by using a non-consumable vacuum electric arc melting process. The VTiCuHfZr high-entropy alloy prepared according to the preparation method comprises a BCC+HCP solid solution, is simple in structure, and has high corrosion resistance and abrasion performance. The VTiCuHfZr high-entropyalloy makes up the shortfall of a traditional alloy, and can be used for working conditions of corrosion resistance and abrasion performance.