The invention discloses a copper sulfide ore combination collector suitable for graded regrind of tailings. The raw material of the copper sulfide ore combination collector is sodium butyl xanthate, 3-chloropropene reacts with sodium butyl xanthate to generate acrylic butyl xanthate through a substitution reaction, then the acrylic butyl xanthate reacts with bromine water to generate 1,2-bromo butyl xanthate propane ester through an addition reaction, the 1,2-bromo butyl xanthate propane ester is one of the components of the target combination collector, the other component of the combinationcollector is sodium dodecyl sulfate, and 90-95% of the 1,2-bromo butyl xanthate propane ester and 5-10% of the sodium dodecyl sulfate are taken according to the mass percent to be mixed in a conical flask at the indoor temperature so as to obtain the copper sulfide ore flotation combination collector. The collector has high selectivity and collectability, also has better foaming performance, and can achieve the separation of copper sulfide mineral and gangue mineral well.