The invention discloses a novel integrated manufacturing process and method based on plastic master batch. The novel integrated manufacturing process and method comprises: carrier grinding, color material grinding, ingredient grinding, auxiliary agent grinding, mixing grinding, extrusion granulation, cooling, drying, screening, weighing and packaging. According to the present invention, the antioxidant, the antistatic agent, the flame retardant, the antibacterial agent and the low-temperature-resistant plasticizer are added in the preparation process, such that the oxidation resistance, the antistatic property, the high temperature resistance, the antibacterial property and the low temperature resistance of the plastic master batch can be effectively improved, the color change is not easily generated, the good compatibility and the good dispersibility can be achieved, the plastic production quality can be ensured, and the plastic damage can be effectively avoided; and various materialsare separately grinded and are finally subjected to mixing grinding treatment so as to effectively ensure the mixing degree of various materials, and the extrusion molding and cooling drying treatment is directly performed after the mixing grinding treatment, such that the master batch production time is shortened, and the pollution on the working environment due to the excessive dust is avoided.