The invention discloses a production method of SiO2 with purity of 99.99%. The production method utilizes kaolin or albite as raw materials or mineral powder containing MgSiO3. The production method comprises: (1) pulverizing the raw materials to powder of 100 meshes or more, (2) quantitatively feeding the powder into a dissolution tank, wherein the use amounts are calculated according to metal oxide content of the materials, adding the equivalent weight of hydrochloric acid or sulfuric acid or nitric acid into the material, and carrying out stirring for 20-30min, (3) filtering the mixture, (4) pickling the filter residues through a low concentration acid solution and washing the filter residues through purified water until the eluent is neutral, and (5) drying the filter residues. The rawmaterials are easy to obtain and have low prices, the process is simple, the equipment is common, and the obtained product is SiO2 powder with purity of 99.99%, is easy to be purify and can be used as the best raw material for producing high-purity SiO2. The method greatly reduces the production cost of high-purity SiO2.