The invention provides a preparation method for ketoprofen lysine, wherein the preparation method comprises the following steps: mixing DL-lysine and a ketoprofen aqueous solution, and generating a salt forming reaction, to obtain a salt forming product system; and carrying out spray drying of the salt forming product system to obtain ketoprofen lysine. The preparation method provided by the invention does not need separation and purification through a solvent-out crystallization method, and the finished product can be obtained. The prepared ketoprofen lysine does not contain residual organicsolvents such as methanol, ethanol and acetone, the product has no solvent residue and has uniform particles, and impurities are not produced in the spray drying process; the obtained ketoprofen lysine and the raw material ketoprofen are consistent in purity, and the yield is high. According to the description of the embodiment, the highest yield of ketoprofen lysine obtained by the preparation method can reach 98%. At the same time, the preparation method avoids the use of a large number of organic solvents, and can significantly reduce the production cost and reduce environmental pressure.