The invention discloses an ester derivative and the application thereof to prevention and treatment of the CCVd (cardiovascular and cerebrovascular diseases), in the formula as shown in the specification, R1, R2, R3 and R4 are respectively and independently selected from H, F or CH3. An in-vitro LCAT (lecithin-cholesterolacyltransferase) activation experiment shows that the compound disclosed by the invention has an LCAT activation effect, and an in-vivo pharmacodynamic experiment shows that the compound disclosed by the invention can improve an HDL level so as to conclude that the compound disclosed by the invention can be used for preventing or treating the cerebrovascular disease, the CHD (Coronary Heart Disease), the arteriosclerosis, the arteriosclerotic heart disease, the peripheralvascular disease, the dyslipidemia, the HDL hypocholesterolemia, the LDL hypercholesterolemia and the like.