An exemplary embodiment provides a method of treating an environment (aquatic or land) to remediate an infestation of mollusks, either active or in hibernation, to remediate a mollusk infestation. Themethod includes the steps of: selecting an amount of a formulation (solid or liquid) comprising a saponin; and distributing this formulation in the environment having an infestation of mollusks. Whenthe environment is land, the steps of the method may include distributing the formulation on the land, flooding the land, for example by irrigation or seasonal rains, to release the saponin that disperses in the water to thereby cause a concentration of saponin in the water for a time effective to remediate mollusks. When the environment is water, the formulation may be distributed into the waterto cause a saponin concentration for an effective time to remediate mollusks.