The invention provides a method for chemically removing trace cyclopentadiene from piperylene. Trace cyclopentadiene refers to that the mass content of cyclopentadiene in piperylene is less than or equal to 1%. The method comprises the following steps: (1) adding n-butanol into potassium hydroxide at room temperature and carrying out stirring until potassium hydroxide is completely dissolved so asto obtain a solution A; (2) adding piperylene and cyclohexanone into the solution A at room temperature and carrying out stirring to obtain a mixed solution B; (3) subjecting the solution B to atmospheric distillation to obtain an effluent C and an in-bottle distillate D, wherein the effluent C is refined piperylene in which the content of cyclopentadiene may drop to 10 ppm or less; and (4) cyclically using the distillate D, and adding piperylene into the distillate D to realize reuse of the distillate D for removal of trace cyclopentadiene from piperylene, wherein in the step (1), the mass ratio of n-butanol to potassium hydroxide is 5-20: 1.