The invention discloses a powder coating extruder. The powder coating extruder comprises an upper pressing cover, a cooling device, a box body, an inspection door, a bracket, a coating extrusion device, a control instrument, an exhaust fan, an air bag, an electromagnetic pulse valve and an injection pipe. The box body is provided with an upper box body. The upper box body is detachably connected with the upper pressing cover. The electromagnetic pulse valve is on one side of the box body. The exhaust fan is arranged on one side of the interior of the box body. The control instrument is arranged on one side of the exterior of the box body. The inspection door is arranged on the side, different from the exterior of the control instrument, of the box body. The thermosetting powder coating extruder with the cooling device is simple in structure; heat produced during working can be effectively absorbed; thermosetting powder adhering to the wall in a feeding segment is effectively removed so that the thermosetting powder can be fully mixed; and the utilization rate is increased.