The invention discloses a device for fixing a protection plate in replacement of a furnace column of a coke oven. The device comprises at least two protection plate jacking tools, wherein the two protection plate jacking tools are symmetrically arranged at two sides of a to-be-replaced furnace column; each protection plate jacking tool comprises a support structure, a limiting structure, a fixing structure and a jacking structure; each limiting structure and each jacking structure are arranged on the corresponding support structure; each limiting structure is used for limiting the corresponding support structure; each jacking structure is used for withstanding a coke oven protection plate; and each fixing structure is arranged on the corresponding limiting structure and is used for fixing the support structure on the furnace column. The protection plate does not need to be dismantled when the furnace column is replaced, so that the workload is reduced and the labor intensity is reduced. A small-specification hoisting machine can be selected, so that reduction of the construction cost is facilitated. The method is simple, convenient to operate and low in cost, and can be generalized to fixing of the protection plate in replacement of the furnace column of the coke oven with any specification.