The invention provides an electro-static protection circuit and method and a display device. The electro-static protection circuit comprises an electro-static release unit and an electro-static protection unit; the electro-static protection unit is used for controlling a signal line and an electro-static release line to be not connected when the signal line does not exist static electricity, when the signal line exists positive static electricity so that a value ascended by a potential on the signal line is smaller than a first predetermined potential difference or when the signal line exists negative static electricity so that the value descended by the potential on the signal line is smaller than a second predetermined potential difference. According to the electro-static protection circuit and method and the display device provided by the invention, the problems that signals are lost, a display panel cannot normally display and the product yield is reduced due to a fact that a leakage current occurs when the display panel works normally in the presence of an electro-static release channel in the prior art are solved.