The invention relates to synthesis of a terminal alkynyl bromide. The synthesis includes the steps of: 1) weighing 11.6 mmol of Br(CH2)10Br and adding the Br(CH2)10Br into a 25 ml three-necked flask, adding 5-10 ml of dry DMF for protection; 2) slowly adding 12 mmol of sodium acetylide (18% in xylene/light oil, 95% purity) to the solvent system protected by nitrogen gas, and performing a reaction at 55 DEG C for 24-48 h until the solution is changed from yellow to milky white; 3) after the reaction is finished, dissolving the reaction product in CHCl3 and filtering the solution, and water-washing an organic phase for two times; and 4) performing rotary evaporating concentration and column chromatography separation, and performing TLC detection to a flow-out substance with n-hexane as a mobile phase.