The invention belongs to the field of health care products, and particularly relates to compound healthcare wine containing abelmoschus manihot as well as a preparation method thereof and an application thereof. The compound healthcare wine is prepared from the following components in parts by weight: 70-90 parts of sticky rice, 0.25-0.75 part of distiller's yeast, 0.1-0.3 part of active brewer's dried yeast, 25-35 parts of abelmoschus manihot, 12-20 parts of lophatherum gracile, 10-18 parts of rhizoma acori graminei, 8-15 parts of folium cortex eucommiae, 5-15 parts of caulis bambusae in taeniam, 10-20 parts of fig, 2-8 parts of bamboo fungus and 3-10 parts of grass of meadow rue. The compound healthcare wine containing abelmoschus manihot provided by the invention is low in preparation cost; and the prepared compound healthcare wine is rich in nutrition and health care components, has a remarkable anti-fatigue effect, and has prevention and auxiliary treatment effects on chronic fatigue syndrome. Meanwhile, the compound healthcare wine is clear in wine body, is soft, sweet and thick in mouthfeel, is free of strong traditional Chinese medicine taste, and is strong in stability.