The invention discloses a desulfurization purification system of coke oven gas, wherein the desulfurization purification system is mainly composed of a pre-processing system, a desulfurization tower and a circulatory system; the pre-processing system includes a primary cooler, an electrical tar precipitator, a spray-type saturator, a final cooling tower and a benzene washing tower which are sequentially connected with a coke oven gas pipe; the circulatory system includes a regeneration tower; the top of the desulfurization tower is provided with a purified coal gas outlet, and the desulfurization tower is connected with the benzene washing tower and the regeneration tower. The technological system has high desulfurization efficiency; purified coal gas can be directly used for urban civil use, metallurgical industry and the like; after desulfurization and purification, the content of hydrogen sulfide can be reduced to 0.02 g/m<3>, and the content of hydrogen cyanide can be reduced to 0.1 g/m<3>.