The present invention relates to a velcro inserting type universal synthetic resin mask with a replaceable filter, an injection molding apparatus therefor, and a manufacturing method thereof. The velcro inserting type universal synthetic resin mask with a replaceable filter according to an embodiment of the present invention comprises: a mask guide with a rim-like shape which supports a filter insertion portion therein and is formed of a synthetic resin by an injection molding process using an upper mold and a lower mold along with the filter insertion portion; and a velcro for attachment of a filter which is placed at a front portion of a velcro entity for attachment of a filter forming portion of the upper mold during 10 the injection molding process for the mask guide and the filter insertion portion and formed on the mask guide when inserted such that the velcro for attachment of a filter is fixed through a velcro entity insertion hole of the upper mold. According to the present invention, manufacturing time can by greatly reduced by using a one-stop injection molding using molds, and hygienic 15 conditions can be improved by replacing filters.