The invention discloses a multi-optimized high pressure separator. The length-diameter ratio is (2.5-5.5):1; a feeding opening is formed in the side surface of the cylinder body and above the liquid surface; the height of the liquid surface accounts for 10-15% of the length of the tangential line of the cylinder body; the distance between the central line of the feeding opening and the middle line of the cylinder body accounts for 15-40% of the length of the tangential line of the cylinder body; a heavy component discharging opening is formed at the lower side of the cylinder body of the high pressure separator; a light component discharging opening is formed at the upper side of the cylinder body; a conical structure is adopted for the part from the lower end of the cylinder body to the heavy component discharging opening; the conical degree is 40-120 degrees. The multi-optimized high pressure separator is suitable for heavy oil hydrogenation process, direct coal liquefaction process and oil-coal mixing process in all of which the solid content is relatively high at an environment of relatively high operation pressure; the suitable operation temperature range is relatively wide, the separation effect can be well realized, the coking rate is low and no residue is left.