The invention relates to a graft hybridization method, in particular to a red wolfberry and black wolfberry graft hybridization method. The method comprises the following steps: grafting, to be specific, using a red wolfberry twig as a root stock, and using a black wolfberry twig with strong affinity as a scion; hybridizing, to be specific, selecting a successively grafted and vigorously growing plant as a hybridization parent. The method is unique and has strong affinity and high survival rate.