The invention relates to a medlar, hot pepper and eggplant grafting hybridization method which comprises two steps of grafting and sexual hybridization, wherein in the first step, a medlar plant is used as a stock, and a hot pepper or eggplant epicormic branch is used as a cion; and in the second step, a successively grafted vigorous plant is used as a hybridization parent. The hybridization is carried out by adopting the following steps of: 1, castrating a female parent: selecting a bug with good growth position and large alabastrum, pushing petals aside and then lightly removing stamen; 2, touching head: firstly, fertilizing and embroidering: on the head of a castrated flower, lightly oppositely touching heads of flowers as male parents to ensure that mucus on the heads of the flowers as the male parents is adhered to the heads of the female parents; and 3, bagging, hanging plates: after the heads are touched, when the male parents are fertilized, lightly tying the petals of the fertilized flower for keeping the humidity, bagging and hanging the plate, making out the hybridization date and the variety names of the male parents and the female parents, and repeatedly fertilizing once in the next day.