The invention relates to preparation formulations of a sodium pyruvate freeze-dried powder injection, an injection and a solid agent and production processes thereof, in particular to a method and a technology for preparing pyruvate and a freeze-dried powder injection, an injection and a solid agent made of the pyruvate. The raw materials of sodium pyruvate (containing calcium and potassium) is synthesized by the following steps of: reacting pyruvic acid and sodium carbonate (salts containing organic acid) produced by fermentation and chemical synthesis to generate sodium pyruvate (and corresponding salts) at a reaction temperature of 20-90 DEG C for 60-70 min; filtering in vacuum; washing the crystal with ethyl acetate and ethanol for 3-5 times; drying in vacuum to obtain a product with the purity higher than 99 percent; and preparing the product into the preparation formulations of a sodium pyruvate freeze-dried powder injection, an injection and a solid agent.