The invention relates to a combined cycle generation system of a high-pressure oxygen-enriched combustion fluidized bed, which is used for solving the problem of economy of oxygen-enriched combustion. The invention has the technical scheme that the combined cycle generation system of the high-pressure oxygen-enriched combustion fluidized bed comprises a working medium circulating system, an oxygen gas supply and flue gas recirculation system and a fuel conveying device, wherein the overall process of the whole system from the oxygen preparation of air separation, the combustion and the heat exchange of a boiler, the work applying of a high-pressure gas turbine until the CO2 trapping of flue gas is persistently finished at high pressure, and the compression energy consumption and the decompression loss are greatly reduced. The invention can condense water in the flue gas which is unserviceable originally in combustion at normal pressure into liquid water, thereby utilizing the releasedlatent heat of vaporization, which lowers the flue gas loss to about 1%, enhances the efficiency of the boiler greatly and can also enhance the output of the gas turbine by about 3-5%. Because of high pressure in an exhaust-heat boiler, liquid-state CO2 can be obtained only by cooling the flue gas to about 25 DEG C through cooling water. Compared with a normal-pressure oxygen-enriched combustion mode adopting multistage compression and refrigeration, the energy saving of the invention is larger.